BDBM22352 1,3-Diarylprop-2-yn-1-one, 13i::1-(3,4-difluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-yn-1-one::CHEMBL197573

SMILES CS(=O)(=O)c1ccc(cc1)C#CC(=O)c1ccc(F)c(F)c1

InChI Key InChIKey=ZYQKSSGGSWACEA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 22352   

TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University of Alberta

LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  3.10E+3nMpH: 8.0 T: 2°CAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University of Alberta

LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  500nMAssay Description:The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLipoxygenase(Solanum tuberosum (potato))
University of Alberta

LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  400nMAssay Description:The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University of Alberta

LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  3.10E+3nMAssay Description:In vitro inhibitory activity against ovine cyclooxygenase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  500nMAssay Description:In vitro inhibitory activity against ovine cyclooxygenase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  3.20E+3nMAssay Description:In vitro inhibitory activity against 15-lipoxygenase obtained from soybeanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  400nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase obtained from potatoMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM22352(1,3-Diarylprop-2-yn-1-one, 13i | 1-(3,4-difluoroph...)
Affinity DataIC50:  3.20E+3nMAssay Description:The lipoxygenase inhibitor screening assay detects and measures the hydroperoxides produced in the lipoxygenation reaction using a purified lipoxygen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed