BDBM223674 3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r)- 1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2- yl}-1,2,4-oxadiazol- 5(4h)-one::US9540377, 11.100::US9540377, 11.117::US9540377, 11.118

SMILES C[C@@H](Nc1nc(nc2nc(N3CCOCC3c3ccccc3Cl)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1)C1CCC1

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 223674   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223674(3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...)
Affinity DataIC50:  0.936nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223674(3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...)
Affinity DataIC50:  0.568nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM223674(3-{8-[3-(2- chlorophenyl)morph- olin-4-yl]-6-{[(1r...)
Affinity DataIC50:  3.77nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent