BDBM224295 6-{[(1r)-1-cyclobutylethyl]amino}- 7-[(trans-4-ethylcyclohexyl)methyl]- 8-[(3r)-3-phenylmorpholin-4-yl]- 7h-purine-2-carboxylic acid::US9540377, 18.21

SMILES CC[C@H]1CC[C@H](Cn2c(nc3nc(nc(N[C@H](C)C4CCC4)c23)C(O)=O)N2CCOC[C@H]2c2ccccc2)CC1

InChI Key InChIKey=YZQMOCBVNBZDLT-XAISMOLKSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224295   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224295(6-{[(1r)-1-cyclobutylethyl]amino}- 7-[(trans-4-eth...)
Affinity DataIC50:  0.548nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent