BDBM224650 3-[6-{[(1r)-1- cyclobutylethyl]amino}-7- [(trans-4- methylcyclohexyl)methyl]- 8-(phenylsulfanyl)-7h- purin-2-yl]-1,2,4- oxadiazol-5(4h)-one::US9540377, 19.1

SMILES C[C@@H](Nc1nc(nc2nc(Sc3ccccc3)n(C[C@H]3CC[C@H](C)CC3)c12)-c1noc(=O)[nH]1)C1CCC1

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224650   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM224650(3-[6-{[(1r)-1- cyclobutylethyl]amino}-7- [(trans-4...)
Affinity DataIC50:  0.763nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent