BDBM22893 CHEMBL512::Ranitidine::ZANTAC::dimethyl[(5-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine
SMILES CN\C([CH-][N+]([O-])=O)=[NH+]/CCSCc1ccc(CN(C)C)o1
InChI Key InChIKey=HZIQBJWHRYXWSD-UHFFFAOYSA-O
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 22893
Affinity DataIC50: >5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cellsMore data for this Ligand-Target Pair
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCECMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMAssay Description:The compound was evaluated for the inhibition of human AcetylcholinesteraseMore data for this Ligand-Target Pair
Affinity DataIC50: 650nMAssay Description:Inhibition of guinea pig acetylcholinesteraseMore data for this Ligand-Target Pair
TargetPotassium-transporting ATPase alpha chain 1/subunit beta(Homo sapiens (Human))
Ortho Pharmaceutical
Curated by ChEMBL
Ortho Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antisecretory activity evaluated by the inhibition of 14C -AP uptake in isolated rabbit parietal cells stimulated by exogenous histamineMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Hoechst Pharmaceutical Research Laboratories
Curated by PDSP Ki Database
Affinity DataIC50: 3.40E+3nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair