BDBM232239 N-3-trifluoromethylbenzoyl-L-leucine-glycine nitrile (35)

SMILES CC(C)C[C@H](NC(=O)c1cccc(c1)C(F)(F)F)C(=O)NCC#N

InChI Key InChIKey=YLGLXVDHNPHGMY-ZDUSSCGKSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 232239   

TargetSecreted cathepsin L 1(Fasciola hepatica (Liver fluke))
Dublin City University

LigandPNGBDBM232239(N-3-trifluoromethylbenzoyl-L-leucine-glycine nitri...)
Affinity DataIC50:  9.10E+3nMAssay Description:The protease was activated by the addition of dithiothreitol, ethylenediaminetetraacetic acid (EDTA), and sodium acetate followed by incubation at 37...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM232239(N-3-trifluoromethylbenzoyl-L-leucine-glycine nitri...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human cathepsin L using Z-L-R-AMC as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by spectroph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetToxopain-2(Toxoplasma gondii)
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM232239(N-3-trifluoromethylbenzoyl-L-leucine-glycine nitri...)
Affinity DataIC50:  120nMAssay Description:Inhibition of Toxoplasma gondii cathepsin L using Z-L-R-AMC as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed