BDBM234355 9-Benzyl-2,3,8,9,10,11-hexahydro-imidazo[1,2-c]pyrido[4′,3′:4,5]thieno[3,2-e]pyrimidine (13)

SMILES C(N1CCc2c(C1)sc1N=CN3CCN=C3c21)c1ccccc1

InChI Key InChIKey=CRZXKXBRUBQZME-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 234355   

TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
University of Bonn

LigandPNGBDBM234355(9-Benzyl-2,3,8,9,10,11-hexahydro-imidazo[1,2-c]pyr...)
Affinity DataKi:  2.36E+3nM ΔG°:  -7.67kcal/mole IC50:  3.09E+3nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University of Bonn

LigandPNGBDBM234355(9-Benzyl-2,3,8,9,10,11-hexahydro-imidazo[1,2-c]pyr...)
Affinity DataIC50:  8.99E+4nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bonn

LigandPNGBDBM234355(9-Benzyl-2,3,8,9,10,11-hexahydro-imidazo[1,2-c]pyr...)
Affinity DataIC50:  2.18E+4nMpH: 7.3 T: 2°CAssay Description:Cholinesterase inhibition was assayed spectrophotometrically at 412 nm at 25°C [Pietsch et al., J. Med. Chem., 48:8270-8288; Ellman et al., Bioch...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed