BDBM235735 US9359371, 3

SMILES COc1ccc(CNc2nc(ncc2C(=O)NCc2ccccc2)N2CC3CC3C2)cc1Cl

InChI Key InChIKey=QFAMNDUERIPOEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 235735   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM235735(US9359371, 3)
Affinity DataIC50:  12.9nMpH: 7.5Assay Description:To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Xuanzhu Pharma

US Patent
LigandPNGBDBM235735(US9359371, 3)
Affinity DataIC50:  8.89nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Homo sapiens (Human))
Xuanzhu Pharma

US Patent
LigandPNGBDBM235735(US9359371, 3)
Affinity DataIC50:  0.910nMpH: 7.5Assay Description:The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent