BDBM235762 US9359371, 46
SMILES COc1ccc(CNc2nc(ncc2C(=O)NCCN2CCN(C)CC2)N2CCC3(CC3)C2)cc1Cl
InChI Key InChIKey=WXVWOXLABRWNAU-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 235762
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Homo sapiens (Human))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: 14.9nMpH: 7.5Assay Description:To a 96-well plate, 20 μL, of 10 μM FL-cGMP as the substrate was added; then 1 μL, of solution of the compound in DMSO or DMSO solutio...More data for this Ligand-Target Pair
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Homo sapiens (Human))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:To a 96-well plate, 20 μL of 10 μM FL-cGMP as the substrate was added; then 1 μL solution of the compound in DMSO or DMSO solution wit...More data for this Ligand-Target Pair
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: 310nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase [537-875](Homo sapiens (Human))
Xuanzhu Pharma
US Patent
Xuanzhu Pharma
US Patent
Affinity DataIC50: 0.310nMpH: 7.5Assay Description:The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (35 μg/mL) in Tris-HCl buffer of pH 7.5. 1 μM cGMP and...More data for this Ligand-Target Pair