BDBM235961 US9365546, 284

SMILES Cc1cnc(cc1-n1c(C)cc(OCc2ccc(F)cc2F)c(Cl)c1=O)-c1ccnc(n1)C(C)(C)O

InChI Key InChIKey=WJYGDQYYYZYICM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 235961   

Target5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2(Homo sapiens (Human))
Confluence Life Sciences

US Patent
LigandPNGBDBM235961(US9365546, 284)
Affinity DataIC50:  6.40nMpH: 7.5 T: 2°CAssay Description:Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2(Homo sapiens (Human))
Confluence Life Sciences

US Patent
LigandPNGBDBM235961(US9365546, 284)
Affinity DataIC50:  144nMpH: 7.5 T: 2°CAssay Description:Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2(Homo sapiens (Human))
Confluence Life Sciences

US Patent
LigandPNGBDBM235961(US9365546, 284)
Affinity DataIC50:  138nMpH: 7.5 T: 2°CAssay Description:Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A/MAP kinase-activated protein kinase 2(Homo sapiens (Human))
Confluence Life Sciences

US Patent
LigandPNGBDBM235961(US9365546, 284)
Affinity DataIC50:  7.30nMpH: 7.5 T: 2°CAssay Description:Kinase reactions is carried out in a 384-well plate (Matrical, MP101-1-PP) in 20 mM HEPES pH 7.5, 10 mM MgCl2, 0.0005% Tween-20, 0.01% BSA, 1 mM DTT,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent