BDBM23702 3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluorophenyl)carbonyl]-1H-pyrazole::N-Benzoylpyrazole deriv., 4

SMILES Cc1ccc(C(=O)c2ccn(n2)C(=O)c2ccc(F)cc2)c(C)c1

InChI Key InChIKey=XNRMQSNQFCESPA-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23702   

TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataKi:  24nM ΔG°:  -10.4kcal/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataIC50:  120nMAssay Description:Thrombin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataAssay Description:Cathepsin D assays were monitored with a Fluoroskan Ascent FL microtiter plate reader at excitation and emission wavelengths of 340 and 390 nm, respe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataAssay Description:Kallikrein activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataAssay Description:Reactions for aminopeptidase M activity were monitored at 405 nm using a SpectraMax Plus microplate reader. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsin-C(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataIC50:  120nMAssay Description:Chymotrypsin activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentrati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataIC50:  1.10E+3nMAssay Description:Urokinase activity was monitored at excitation and emission wavelengths of 355 and 460 nm, respectively. For all compounds tested, the concentration ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed