BDBM237494 US9393232, 4.1::US9393232, 4.1a::US9393232, 4.1b

SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c3ccsc3)c2c1

InChI Key InChIKey=BRBCSVDUUHHTIS-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 237494   

TargetBromodomain-containing protein 2 [1-473](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM237494(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Affinity DataIC50:  18nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [1-435](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM237494(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Affinity DataIC50:  14nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain testis-specific protein [1-397](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM237494(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Affinity DataIC50:  31nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [1-477](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM237494(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Affinity DataIC50:  4.90E+3nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [1-477](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM237494(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Affinity DataIC50:  34nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [1-477](Homo sapiens (Human))
Beigene

US Patent
LigandPNGBDBM237494(US9393232, 4.1 | US9393232, 4.1a | US9393232, 4.1b)
Affinity DataIC50:  100nMpH: 7.5Assay Description:The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent