BDBM23928 1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]benzene::CHEMBL296411::trans-Stilbene Derivative, 4a

SMILES COc1ccc(\C=C\c2cc(OC)cc(OC)c2)cc1

InChI Key InChIKey=GDHNBPHYVRHYCC-SNAWJCMRSA-N

Data  3 KI  14 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 23928   

TargetAryl hydrocarbon receptor(Oryctolagus cuniculus (rabbit))
Institut Claudius Regaud

LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataKi:  7.70nM ΔG°:  -10.3kcal/molepH: 7.6 T: 2°CAssay Description:Cytosols from rabbit liver were incubated with [3H]-TCDD and 12 concentrations of unlabeled test ligands. IC50 values were determined using the itera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor(Homo sapiens (Human))
Institut Claudius Regaud

LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataKi:  261nMAssay Description:Cytosols from MCF-7 cells expressed ER-alpha isoform were incubated with [3H]-estradiol and eight concentrations of unlabeled test ligands. IC50 val...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAryl hydrocarbon receptor(Homo sapiens (Human))TBA
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataKi:  1.30E+8nMAssay Description:Binding affinity to aryl hydrocarbon receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetCytochrome P450 1A1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  830nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes epressing human cytochrome P450 1A1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced increase of intracellular calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataEC50:  1.70E+3nMAssay Description:Agonist activity at rat TRPA1 expressed in HEK293 cells assessed as induction of intracellular calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  3.00E+3nMAssay Description:Antagonist activity at rat TRPA1 expressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced increase of intracellular calcium l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  3nMAssay Description:Inhibtion of CYP1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  1.23E+3nMAssay Description:Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate addition inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  8.00E+3nMAssay Description:Antiproliferative activity against MDR human HL60R cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  1.00E+4nMAssay Description:Antiproliferative activity against human K562 cell line expressing Bcr-AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibosyldihydronicotinamide dehydrogenase [quinone](Homo sapiens (Human))
Purdue University

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  1.46E+4nMAssay Description:Inhibition of human quinone reductase 2 expressed in Escherichia coli BL21(DE3) using N-methyldihydronicotinamide as co-substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  3.62E+3nMAssay Description:Inhibition of human 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University Of Campania "L. Vanvitelli

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  760nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as A23187-stimulated LTB4 production preincubated for 15 mins followed by A23187 addition and measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAromatase(Homo sapiens (Human))TBA
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  1.36E+4nMAssay Description:Inhibition of human AromataseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome P450 1B1(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  790nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1B1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Seoul National University

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of ethoxyresorufin O-deethylation (EROD) in bicistronic bacterial membranes expressing human cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataEC50:  1.56E+6nMAssay Description:Binding affinity to recombinant C1 domain of PKCalpha expressed in Escherichia coli BL21 (DE3) after 45 mins by fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
University Of Alberta

Curated by ChEMBL
LigandPNGBDBM23928(1,3-dimethoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]be...)
Affinity DataIC50:  1.67E+3nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate assessed as PGE2 production preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed