BDBM245244 US9428500, 38

SMILES COc1ccccc1C#Cc1ccnc2[nH]c3ccc(cc3c12)-c1ccc(cc1)N1CCN(C)CC1

InChI Key InChIKey=BWIADMVUWVTNBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 245244   

TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Universita Degli Studi Di Milano—Bicocca

US Patent
LigandPNGBDBM245244(US9428500, 38)
Affinity DataIC50:  750nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Universita Degli Studi Di Milano—Bicocca

US Patent
LigandPNGBDBM245244(US9428500, 38)
Affinity DataIC50:  750nMAssay Description:Inhibition of recombinant GST-tagged wild type ALK (1064 to 1427 residues) (unknown origin) expressed in Sf9 cells using TMB peptide as substrate pre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Universita Degli Studi Di Milano—Bicocca

US Patent
LigandPNGBDBM245244(US9428500, 38)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant GST-tagged ALK L1196M mutant (1064 to 1427 residues) (unknown origin) expressed in Sf9 cells using TMB peptide as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Universita Degli Studi Di Milano—Bicocca

US Patent
LigandPNGBDBM245244(US9428500, 38)
Affinity DataIC50:  290nMpH: 7.5 T: 2°CAssay Description:GST-tagged recombinant wild-type or L1196M mutated ALK kinase (rALK) was expressed in Sf9 insect cells using the pBacPAK baculovirus vector system (C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent