BDBM249316 US10300060, Example 8-1::US10765676, Example 8-1::US9463192, 8-1::US9763943, 8-1::US9993479, 8-1

SMILES Cc1cn(nn1)-c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(Cl)cnc2N)nc1)C(F)(F)F

InChI Key InChIKey=LJZXQCAFSGXUDA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249316   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249316(US10300060, Example 8-1 | US10765676, Example 8-1 ...)
Affinity DataIC50:  1nMT: 2°CAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249316(US10300060, Example 8-1 | US10765676, Example 8-1 ...)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249316(US10300060, Example 8-1 | US10765676, Example 8-1 ...)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249316(US10300060, Example 8-1 | US10765676, Example 8-1 ...)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249316(US10300060, Example 8-1 | US10765676, Example 8-1 ...)
Affinity DataIC50:  1nMAssay Description:TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent