BDBM249325 US10300060, Example 15-4::US10765676, Example 15-4::US9463192, 15-4::US9763943, 15-4::US9993479, 15-4

SMILES Nc1ncc(Cl)cc1-c1ccc(Oc2ncc(NC(=O)Nc3ccc(cc3-n3cccn3)C(F)(F)F)cn2)cc1

InChI Key InChIKey=DZUYLXXBVLCLIN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249325   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249325(US10300060, Example 15-4 | US10765676, Example 15-...)
Affinity DataIC50:  1nMT: 2°CAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249325(US10300060, Example 15-4 | US10765676, Example 15-...)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249325(US10300060, Example 15-4 | US10765676, Example 15-...)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249325(US10300060, Example 15-4 | US10765676, Example 15-...)
Affinity DataIC50:  1nMAssay Description:On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249325(US10300060, Example 15-4 | US10765676, Example 15-...)
Affinity DataIC50:  1nMAssay Description:TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent