BDBM249338 US10300060, Example 15-105::US10765676, Example 15-105::US9463192, 15-105::US9763943, 15-105::US9993479, 15-105

SMILES CN(C)S(=O)(=O)c1ccc(cc1NC(=O)Nc1cnc(Oc2ccc(cc2)-c2cc(cnc2N)C(F)(F)F)nc1)C(F)(F)F

InChI Key InChIKey=SVEGJHMWSORDBT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249338   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249338(US10300060, Example 15-105 | US10765676, Example 1...)
Affinity DataIC50:  4nMT: 2°CAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249338(US10300060, Example 15-105 | US10765676, Example 1...)
Affinity DataIC50:  4nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249338(US10300060, Example 15-105 | US10765676, Example 1...)
Affinity DataIC50:  4nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249338(US10300060, Example 15-105 | US10765676, Example 1...)
Affinity DataIC50:  4nMAssay Description:On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249338(US10300060, Example 15-105 | US10765676, Example 1...)
Affinity DataIC50:  4nMAssay Description:TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent