BDBM249352 US10300060, Example 23-7::US10765676, Example 23-7::US9463192, 23-7::US9763943, 23-7::US9993479, 23-7

SMILES FC(F)(F)c1ccc(c(NC(=O)Nc2cnc(Oc3ccc(cc3)-c3cnc4[nH]ccc4c3)nc2)c1)-c1cccnc1

InChI Key InChIKey=DVMMNZKIWHSVNM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 249352   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249352(US10300060, Example 23-7 | US10765676, Example 23-...)
Affinity DataIC50:  2nMT: 2°CAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249352(US10300060, Example 23-7 | US10765676, Example 23-...)
Affinity DataIC50:  2nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249352(US10300060, Example 23-7 | US10765676, Example 23-...)
Affinity DataIC50:  2nMAssay Description:On the day before the assay, CellSenser TrkA-NFAT-bla CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249352(US10300060, Example 23-7 | US10765676, Example 23-...)
Affinity DataIC50:  2nMAssay Description:On the day before the assay, CellSenser™ TrkA-NFAT-b1a CHO-K1 cells were suspended in an assay medium (Opti-MEM1 Reduced Serum Medium (Invitrogen) co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM249352(US10300060, Example 23-7 | US10765676, Example 23-...)
Affinity DataIC50:  2nMAssay Description:TrkA kinase-inhibiting activity in cell systems was measured using CHO-K1 cells expressing human TrkA and NFAT-bla (CellSenser TrkA-NFAT-bla CHO-K1 c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent