BDBM25013 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol::GSK-690693::GSK690693::US10550114, Compound GSK690693
SMILES CCn1c(nc2c(ncc(OC[C@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N
InChI Key InChIKey=KGPGFQWBCSZGEL-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 471 hits for monomerid = 25013
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Human)
Technische Universit������T Dortmund
Technische Universit������T Dortmund
Affinity DataIC50: 0.400nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturers instructions. The kinases A...More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of AKT1 (unknown origin) after 1 hr by Z'-LYTE kinase assay in presence of 75 uM ATPMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of AKT1 (unknown origin) using biotinylated-STK as substrate after 45 mins by HTRF assayMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 2nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
Affinity DataKd: 2.10nMAssay Description:Binding constant for AKT2 kinase domainMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataKd: 2.20nMAssay Description:Binding constant for AKT1 kinase domainMore data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Human)
Virginia Commonwealth University
Curated by ChEMBL
Virginia Commonwealth University
Curated by ChEMBL
Affinity DataIC50: 2.30nMAssay Description:iFLiK and HTRF studies were carried out as described in Z. Fang, J. R. Simard, D. Plenker, H. D. Nguyen, T. Phan, P. Wolle, S. Baumeister, D. Rauh, A...More data for this Ligand-Target Pair
Affinity DataKd: 2.40nMAssay Description:Binding constant for PRKCH kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3nMAssay Description:Binding constant for AKT3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 3.10nMAssay Description:Binding constant for PRKG2 kinase domainMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PknB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 3.20nMAssay Description:Binding constant for PKNB(M.tuberculosis) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 5.30nMAssay Description:Binding constant for PRKCE kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 7.20nMAssay Description:Binding constant for PRKX kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8.90nMAssay Description:Binding constant for PAK7 kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of AKT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition Akt3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 13nMAssay Description:Binding constant for PKAC-beta kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of AKT2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from radiolabeled AT...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition Akt2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding constant for PRKCQ kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 18nMAssay Description:Binding constant for PAK4 kinase domainMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Ambit Biosciences
Curated by ChEMBL
Ambit Biosciences
Curated by ChEMBL
Affinity DataKd: 19nMAssay Description:Binding constant for PKAC-alpha kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding constant for PAK6 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 33nMAssay Description:Binding constant for YSK4 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 34nMAssay Description:Binding constant for PKN1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 51nMAssay Description:Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 54nMAssay Description:Binding constant for PRKCD kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 86nMAssay Description:Binding constant for SNARK kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 100nMAssay Description:Binding constant for GSK3B kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for DCAMKL3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Binding constant for KIT(D816V) kinase domainMore data for this Ligand-Target Pair
Affinity DataIC50: 138nMAssay Description:Inhibition of GSK3-beta phosphorylation in human BT474 cellsMore data for this Ligand-Target Pair
Affinity DataKd: 140nMAssay Description:Binding constant for LATS2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 160nMAssay Description:Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Binding constant for ROCK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Binding constant for CIT kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 200nMAssay Description:Binding constant for HIPK3 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 210nMAssay Description:Binding constant for PRKG1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 250nMAssay Description:Binding constant for PRKCI kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 270nMAssay Description:Binding constant for PAK2 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 280nMAssay Description:Binding constant for ROCK1 kinase domainMore data for this Ligand-Target Pair
