BDBM25025 4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]morpholine::thieno[3,2-d]pyrimidine derivative, 20

SMILES C1CN(CCO1)c1nc(nc2ccsc12)-c1cccc2[nH]ncc12

InChI Key InChIKey=GXJBABITGPOFCK-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 25025   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM25025(4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]...)Copy SMILESCopy InChI

Affinity DataIC50:  36nMAssay Description:Inhibition of PI3Kalpha assessed as reduction in PIP3 formation after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Piramed Pharma

LigandBDBM25025(4-[2-(1H-indazol-4-yl)thieno[3,2-d]pyrimidin-4-yl]...)Copy SMILESCopy InChI

Affinity DataIC50:  102nMpH: 7.5 T: 2°CAssay Description:Test compounds were added to reaction buffer containing yttrium silicate (Ysi) polylysine SPA beads (Amersham), and the enzyme was added to the assay...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
antibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
Copy BDB DOI