BDBM250502 US9464103, (6'R,6aR,7r,10aS)-10a-(4-chlorobenzenesulfonyl)-1,4-difluoro-6'-methyl-6,6a,8,9,10,10a-hexahydrospiro[benzo[c]isochromene-7,3'-[1,5,6λ⁵]dioxaphosphinane]-6'-one

SMILES C[P@@]1(=O)OC[C@]2(CCC[C@@]3([C@H]2COc2c(F)ccc(F)c32)S(=O)(=O)c2ccc(Cl)cc2)CO1

InChI Key InChIKey=HYGZSKLILPYKMS-LUJKYOOASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 250502   

TargetAmyloid-beta precursor protein [672-711](Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM250502(US9464103, (6'R,6aR,7r,10aS)-10a-(4-chlorobenz...)
Affinity DataIC50:  421nMpH: 7.0Assay Description:To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent