BDBM25151 9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide::CHEMBL115011::trifluoromethyl ketone, 11

SMILES FC(F)(F)C(=O)CCCCCCC(=O)Nc1cccc(c1)-c1ccccc1

InChI Key InChIKey=MURSHQSEWWUKLX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 25151   

TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)
Affinity DataIC50:  1.40E+3nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)
Affinity DataIC50:  120nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase (HDAC1 and HDAC2)(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)
Affinity DataIC50:  380nMAssay Description:Inhibition of human histone deacetylase (mixture of HDAC1 and HDAC2) prepared from K562 erythroleukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)
Affinity DataIC50:  33nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)
Affinity DataIC50:  1.70E+3nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed