BDBM25154 ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate::furan derivative, 2

SMILES CCOC(=O)c1ccc(o1)C(=O)C(F)(F)F

InChI Key InChIKey=NCAOGPVUVXZUCU-UHFFFAOYSA-N

Data  3 IC50  2 Other

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25154   

TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25154(ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate...)
Affinity DatapH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25154(ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate...)
Affinity DataT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25154(ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate...)
Affinity DataIC50:  550nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25154(ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate...)
Affinity DataIC50:  2.50E+3nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25154(ethyl 5-(2,2,2-trifluoroacetyl)furan-2-carboxylate...)
Affinity DataIC50:  3.10E+3nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed