BDBM25160 N-[(4-methoxyphenyl)methyl]-5-(2,2,2-trifluoroacetyl)thiophene-2-carboxamide::thiophene derivative, 3f

SMILES COc1ccc(CNC(=O)c2ccc(s2)C(=O)C(F)(F)F)cc1

InChI Key InChIKey=KWIVOWDCZJOCGU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 25160   

TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25160(N-[(4-methoxyphenyl)methyl]-5-(2,2,2-trifluoroacet...)
Affinity DataIC50:  210nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25160(N-[(4-methoxyphenyl)methyl]-5-(2,2,2-trifluoroacet...)
Affinity DataIC50:  120nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25160(N-[(4-methoxyphenyl)methyl]-5-(2,2,2-trifluoroacet...)
Affinity DataIC50:  240nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25160(N-[(4-methoxyphenyl)methyl]-5-(2,2,2-trifluoroacet...)
Affinity DataIC50:  180nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
Irbm/Merck Research Laboratories

LigandPNGBDBM25160(N-[(4-methoxyphenyl)methyl]-5-(2,2,2-trifluoroacet...)
Affinity DataIC50:  70nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed