BDBM25376 (R)-(hydroxyethylamino)sulfonamide isostere, 3m::4-methyl-1,7,4-dioxazecan-9-yl N-[(2S,3R)-3-hydroxy-4-[(4-methoxybenzene)(2-methylpropyl)sulfonamido]-1-phenylbutan-2-yl]carbamate::US8501961, 27::US8501961, 3m
SMILES COc1ccc(cc1)S(=O)(=O)N(CC(C)C)C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC1COCCN(C)CCOC1
InChI Key InChIKey=VRPYTXIQAZYPAK-URLMMPGGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 25376
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Purdue Research Foundation
US Patent
Purdue Research Foundation
US Patent
Affinity DataKi: 19nMAssay Description:Enzyme inhibitory assay utilizes a protocol described by Toth and Marshall (Toth, M. V.; Marshall G.R. A simple, continuous fluormetric assay for HIV...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Purdue University
Purdue University
Affinity DataKi: 19nM ΔG°: -10.5kcal/mole IC50: >1.00E+3nMpH: 6.4 T: 2°CAssay Description:The Ki values were determined by substrate cleavage assay using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-Arg-NH2. A standar...More data for this Ligand-Target Pair