BDBM255370 US9481682, 121

SMILES Nc1nccn2c(nc(-c3ccc(cc3OC3CC3)C(=O)Nc3cc(ccn3)C(F)(F)F)c12)[C@@H]1CC[C@H]2CCC(=O)N2C1

InChI Key InChIKey=WMMNTQFZCHUZSM-MJGOQNOKSA-N

Data  20 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 255370   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  0.580nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  12nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  494nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  309nMAssay Description:Inhibition of BLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  64nMAssay Description:Inhibition of BMX (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  717nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  263nMAssay Description:Inhibition of FGR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  530nMAssay Description:Inhibition of FRK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  182nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  865nMAssay Description:Inhibition of LYNB (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProtein-tyrosine kinase 6(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  320nMAssay Description:Inhibition of PTK6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  946nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Srms(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  61nMAssay Description:Inhibition of SRMS (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  277nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase TXK(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  312nMAssay Description:Inhibition of TXK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  430nMAssay Description:Inhibition of YES1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM255370(US9481682, 121)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of recombinant full length BTK (unknown origin) expressed in baculovirus infected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-NH2 peptide as su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB