BDBM25878 5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one::CHEMBL13280::Flunitrazepam::[3H]Rohypnol::[3H]flunitrazepam

SMILES CN1c2ccc(cc2C(=NCC1=O)c1ccccc1F)[N+]([O-])=O

InChI Key InChIKey=PPTYJKAXVCCBDU-UHFFFAOYSA-N

Data  36 KI  5 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25878   

TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)
Affinity DataKi:  3.90nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)
Affinity DataKi:  5.90nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed