BDBM259413 US10457647, Example 12::US11180460, Example 12::US11673868, Example 12::US9512084, 12

SMILES CN(CCOc1c(N)ncnc1-c1cccc(c1)-n1ccc2cc(cc(F)c2c1=O)C1CC1)C(=O)C=C

InChI Key InChIKey=ROYGBUGGEVOCCJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 259413   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259413(US10457647, Example 12 | US11180460, Example 12 | ...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259413(US10457647, Example 12 | US11180460, Example 12 | ...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259413(US10457647, Example 12 | US11180460, Example 12 | ...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM259413(US10457647, Example 12 | US11180460, Example 12 | ...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the present compounds against Btk was assessed in a biochemical enzyme assay. Assay plates in 384 well format were prepare...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent