BDBM259485 US9526727, Comparison Example Table 2, 2''-amino-4-methoxy-5''-oxo-1''-(oxolan-2-ylmethyl)-1'',5''-dihydro-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-imidazole]-6'-carbonitrile
SMILES CO[C@H]1CCC2(Cc3ccc(cc3C22N=C(N)N(CC3CCCO3)C2=O)C#N)CC1
InChI Key InChIKey=UPHWMYMEWKSHEJ-WKJJIOGWSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 259485
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vitae Pharmaceutical
US Patent
Vitae Pharmaceutical
US Patent
Affinity DataIC50: 1.00E+4nMpH: 7.4 T: 2°CAssay Description:Cells were superfused with a bath solution containing (mM): NaCl (137), KCl (4.0), MgCl2 (1.0), CaCl2 (1.8), Glucose (10), HEPES (10), pH 7.4 with Na...More data for this Ligand-Target Pair
Affinity DataIC50: 35nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair