BDBM259485 US9526727, Comparison Example Table 2, 2''-amino-4-methoxy-5''-oxo-1''-(oxolan-2-ylmethyl)-1'',5''-dihydro-3'H-dispiro[cyclohexane-1,2'-indene-1',4''-imidazole]-6'-carbonitrile

SMILES CO[C@H]1CCC2(Cc3ccc(cc3C22N=C(N)N(CC3CCCO3)C2=O)C#N)CC1

InChI Key InChIKey=UPHWMYMEWKSHEJ-WKJJIOGWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 259485   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM259485(US9526727, Comparison Example Table 2, 2''-amino-4...)
Affinity DataIC50:  1.00E+4nMpH: 7.4 T: 2°CAssay Description:Cells were superfused with a bath solution containing (mM): NaCl (137), KCl (4.0), MgCl2 (1.0), CaCl2 (1.8), Glucose (10), HEPES (10), pH 7.4 with Na...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1 [1-454](Homo sapiens (Human))
Vitae Pharmaceutical

US Patent
LigandPNGBDBM259485(US9526727, Comparison Example Table 2, 2''-amino-4...)
Affinity DataIC50:  35nMpH: 4.4Assay Description:The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent