BDBM259823 US9505766, 24

SMILES NC(=O)C(=C\c1ccc(cc1)-c1cn[nH]c1)\C#N

InChI Key InChIKey=BNRLLVUNYCBXNJ-VZUCSPMQSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 259823   

TargetRibosomal protein S6 kinase alpha-3 [399-740](Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM259823(US9505766, 24)
Affinity DataIC50:  5.00E+3nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM259823(US9505766, 24)
Affinity DataIC50:  1.00E+4nMpH: 7.6 T: 2°CAssay Description:Human PLK1 (Millipore, catalog number 14-777M) (7.2 nM) in 20 mM Hepes, pH 7.6, 10 mM MgCl2, 1 mM EDTA, 0.2 mg/mL BSA, and 100 μM ATP was pre-in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRibosomal protein S6 kinase alpha-3 [399-740,C436V](Homo sapiens (Human))
The Regents of The University of California

US Patent
LigandPNGBDBM259823(US9505766, 24)
Affinity DataIC50: >1.50E+5nMpH: 8.0 T: 2°CAssay Description:RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent