BDBM263505 US10561662, Example 74::US11173161, EX 74::US9556130, test 74::n-(4-chlorophenethyl)-2-(4-oxobenzo[d][1,2,3]triazin-3(4h)-yl)acetamide
SMILES Clc1ccc(CCNC(=O)Cn2nnc3ccccc3c2=O)cc1
InChI Key InChIKey=GASJSONKGOIOOV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 263505
Affinity DataKi: 1.24E+3nM ΔG°: -7.49kcal/molepH: 7.4 T: 2°CAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Affinity DataKi: 1.24E+3nMAssay Description:Membranes were removed from −80° C., thawed and diluted in cold radioligand assay buffer (20 mM HEPES pH 7.4/5 mM MgCl2/1 mM CaCl2/Roche protea...More data for this Ligand-Target Pair
Affinity DataKi: 1.24E+3nMAssay Description:Displacement of (S)-N-(1-(2-[3H]-4-methoxyphenyl)propan-2-yl)-2-(2,3-dimethyl-7-oxothieno[2,3-d]pyridazin-6(7H)-yl)acetamide from human GPR139 expres...More data for this Ligand-Target Pair
Affinity DataKi: 1.24E+6nMAssay Description:This membrane based assay measures the ability of compounds to competitively bind GPR139 in stably transfected CHO-TRex membranes. CHO-TRex (Life Tec...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at human GPR139 expressed in CHO-TRex cells assessed as stimulation of calcium signalling incubated for 15 mins by FLIPR assayMore data for this Ligand-Target Pair