BDBM26516 1-[4-(cyclopentylamino)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl]ethan-1-one::BI 2536 analogue, 2b

SMILES CN1CCN(CC1)c1ccc(Nc2ncc(C(C)=O)c(NC3CCCC3)n2)cc1

InChI Key InChIKey=JXEFOTNVTVZSOF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26516   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26516(1-[4-(cyclopentylamino)-2-{[4-(4-methylpiperazin-1...)
Affinity DataIC50:  345nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26516(1-[4-(cyclopentylamino)-2-{[4-(4-methylpiperazin-1...)
Affinity DataIC50:  3.49E+3nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Pfizer

LigandPNGBDBM26516(1-[4-(cyclopentylamino)-2-{[4-(4-methylpiperazin-1...)
Affinity DataIC50:  367nMpH: 7.5 T: 2°CAssay Description:Percent inhibition and IC50 values were determined with ATP concentrations at apparent Km using the Invitrogen SelectScreen Kinase Profiling Service ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed