BDBM267703 (R)-4-(8-amino-5-deutero-3-(1-(3-methoxypropanoyl) piperidin-3-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide::US9718828, Example, 305
SMILES CC1(COC1)C(=O)N1CCC[C@H](C1)c1nc(-c2ccc(cc2)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
InChI Key InChIKey=AHBFBRPGNOVEBK-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 267703
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMAssay Description:Inhibition of human TXKMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human ERG by [35S]-MK499 displacement or iKr channel assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in anti-IgM-induced MIP1betaMore data for this Ligand-Target Pair
Affinity DataIC50: 0.270nMAssay Description:Reversible inhibition of recombinant full length BTK (unknown origin) baculovirus infected Sf9 cells using biotinylated EQEDEPEGDYFEWLE-NH2 peptide a...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Inhibition of human BLKMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human BMXMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 118nMAssay Description:Inhibition of human ERBB4More data for this Ligand-Target Pair
Affinity DataIC50: 361nMAssay Description:Inhibition of human FRKMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 399nMAssay Description:Inhibition of human LYNBMore data for this Ligand-Target Pair
Affinity DataIC50: 66nMAssay Description:Inhibition of human PTK6More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Srms(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of human SRMSMore data for this Ligand-Target Pair
Affinity DataIC50: 167nMAssay Description:Inhibition of human TECMore data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of recombinant full-length His6-tagged BTK (unknown origin) expressed in baculovirus infected Sf9 cells using biotinylated A5 peptide as s...More data for this Ligand-Target Pair