BDBM267790 4-(8-amino-3-{(3R,6S)-6-methyl-1-[(3-methyloxetan-3-yl)carbonyl]piperidin-3-yl}imidazo[1,5-a]pyrazin-1-yl)-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide::US9718828, Example, 396
SMILES C[C@H]1CC[C@H](CN1C(=O)C1CC1)c1nc(-c2ccc(cc2F)C(=O)Nc2cc(ccn2)C(F)(F)F)c2c(N)nccn12
InChI Key InChIKey=JUSWPUDQOKINJO-MAUKXSAKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 28 hits for monomerid = 267790
Affinity DataIC50: <10nMAssay Description:BTK enzymatic activity was determined with the LANCE (Lanthanide Chelate Excite) TR-FRET (Time-resolved fluorescence resonance energy transfer) assay...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 94nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of 6-His-tagged recombinant full length BTK (unknown origin) expressed in baculovirus-transfected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-N...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of BTK in human PBMCMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Reversible inhibition of recombinant full length BTK (unknown origin) baculovirus infected Sf9 cells using biotinylated EQEDEPEGDYFEWLE-NH2 peptide a...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
Affinity DataIC50: 94nMAssay Description:Inhibition of BTK in human whole blood assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with anti-...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human BLKMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human BMXMore data for this Ligand-Target Pair
Affinity DataIC50: 201nMAssay Description:Inhibition of human CSKMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of human ERBB4More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of human FGRMore data for this Ligand-Target Pair
Affinity DataIC50: 111nMAssay Description:Inhibition of human FRKMore data for this Ligand-Target Pair
Affinity DataIC50: 198nMAssay Description:Inhibition of human FYNMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human ITKMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 131nMAssay Description:Inhibition of human LYNBMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human PTK6More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human SRCMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Srms(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human SRMSMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human TECMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of human TXKMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of human YES1More data for this Ligand-Target Pair
Affinity DataIC50: 0.310nMAssay Description:Inhibition of recombinant full length BTK (unknown origin) expressed in baculovirus infected Sf9 cells using Biotin-EQEDEPEGDYFEWLE-NH2 peptide as su...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in cell surface CD69 expression preincubated for 1 hr followed by stimulation with goat anti-hu...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair