BDBM26806 (3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]methyl}benzene)oxane-3,4-diamido::CHEMBL253275::benzimidazole analog., 32

SMILES ONC(=O)[C@H]1COCC[C@H]1NC(=O)c1ccc(Cn2c(nc3ccccc23)C(F)(F)F)cc1

InChI Key InChIKey=PGVYYPZKXKGBLD-JKSUJKDBSA-N

Data  14 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 26806   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 1(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of ADAMTS1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of ADAMTS5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi:  6.70E+3nMAssay Description:Inhibition of ADAMTS4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-15(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP15More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP14More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-16(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP16More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MMP7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Sun Pharma Advanced Research

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50:  130nMAssay Description:Inhibition of TACE in human whole blood assessed as reduction of of LPS-induced TNFalpha production pretreated 15 mins before LPS challenge measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50:  1.40nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of pig TACEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of MMP10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Athens

Curated by ChEMBL
LigandPNGBDBM26806((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(trifluoromethyl)-1...)
Affinity DataIC50:  8.00E+3nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed