BDBM270578 (S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazolin-6- yl)amino)(2- chlorophenyl)methyl- d)-1H-1,2,3-triazol- 1-yl)acetic acid::US10059695, I-10::US10577352, Compound I-10

SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(CC(O)=O)nn3)c3ccccc3Cl)cc12

InChI Key InChIKey=HFRMICLFXNJUSQ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270578   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270578((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...)
Affinity DataIC50:  13nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270578((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...)
Affinity DataEC50: >1.00E+3nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270578((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...)
Affinity DataIC50:  13nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270578((S)-2-(4-(((8-chloro- 4- (neopentylamino) quinazol...)
Affinity DataEC50: >1.00E+3nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent