BDBM270584 (S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropyl)-1H- 1,2,3-triazol-4-yl)(4- fluorophenyl)methyl- d)-N4- neopentylquinazoline- 4,6-diamine::US10059695, I-16::US10577352, Compound I-16

SMILES CC(C)(C)CNc1ncnc2c(Cl)cc(NC(c3cn(nn3)C3(CF)CC3)c3ccc(F)cc3)cc12

InChI Key InChIKey=DKVMOUAUMOHCGA-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 270584   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270584((S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropy...)
Affinity DataIC50:  3.10nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270584((S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropy...)
Affinity DataEC50:  46nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270584((S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropy...)
Affinity DataIC50:  3.10nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM270584((S)-8-chloro-N6-((1- (1- (fluoromethyl) cyclopropy...)
Affinity DataEC50:  46nMpH: 7.0 T: 2°CAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent