BDBM273177 (R)-N-benzyl-1-[7-methyl-5-oxo-6-(propan-2-yl)-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-2-yl]pyrrolidine-2-carboxamide::US10065972, Example 647

SMILES CC(C)c1c(C)nc2sc(nn2c1=O)N1CCC[C@@H]1C(=O)NCc1ccccc1

InChI Key InChIKey=ATRCVPZDWMIPCR-MRXNPFEDSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 273177   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM273177((R)-N-benzyl-1-[7-methyl-5-oxo-6-(propan-2-yl)-5H-...)
Affinity DataIC50:  58nMpH: 8.0Assay Description:The inhibitory action of the test compound on human recombinant KAT-II was determined by the following method.To a reaction mixture (45 μL) cont...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent