BDBM275813 5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- propoxy)pyridin-3- yloxy)-N-(N,N- dimethylsulfamoyl)- 2-fluorobenzamide::US10071957, Example 30

SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(Oc2cnc(OCC(F)(F)C(F)F)c(Cl)c2)cc1F

InChI Key InChIKey=UOURQUTWYWICIZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 275813   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275813(5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- prop...)
Affinity DataIC50:  47.8nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275813(5-chloro-4-(5-chloro- 6-(2,2,3,3-tetrafluoro- prop...)
Affinity DataIC50:  34nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent