BDBM275868 US10071957, Example 87

SMILES CC(C)Oc1ncc(Oc2cc(F)c(cc2C2CC2)C(=O)NS(=O)(=O)N2CCC2)cc1Cl

InChI Key InChIKey=FTFVFAHJHJQWBC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 275868   

TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275868(US10071957, Example 87)
Affinity DataIC50:  2.10nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275868(US10071957, Example 87)
Affinity DataIC50:  1.20E+3nMpH: 7.2Assay Description:Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275868(US10071957, Example 87)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Nav1.5 (unknown origin) by PatchXpress methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275868(US10071957, Example 87)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of Nav1.7 (unknown origin) by PatchXpress methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM275868(US10071957, Example 87)
Affinity DataIC50:  6nMpH: 7.4 T: 2°CAssay Description:Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent