BDBM27614 3-(6-bromo-2-fluoro-3-{1H-pyrazolo[3,4-c]pyridazin-3-ylmethyl}phenoxy)-5-chlorobenzonitrile::annulated pyrazole compound, 6

SMILES Fc1c(Cc2n[nH]c3nnccc23)ccc(Br)c1Oc1cc(Cl)cc(c1)C#N

InChI Key InChIKey=OHQMEDBYNUAVNE-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 27614   

TargetGag-Pol polyprotein [588-1027,K691N,Y769C]/[588-1147,K691N,Y769C](Human immunodeficiency virus type 1)
Roche Palo Alto

LigandPNGBDBM27614(3-(6-bromo-2-fluoro-3-{1H-pyrazolo[3,4-c]pyridazin...)
Affinity DataIC50:  3nM EC50:  4nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027](Human immunodeficiency virus type 1 group M subtyp...)
Roche Palo Alto

LigandPNGBDBM27614(3-(6-bromo-2-fluoro-3-{1H-pyrazolo[3,4-c]pyridazin...)
Affinity DataIC50:  3nM EC50:  1nMpH: 8.0 T: 2°CAssay Description:IC50s were obtained from the inhibition of the RNA-dependent DNA polymerase activity of the HIV-1 reverse transcriptase enzyme using a primer extensi...More data for this Ligand-Target Pair