BDBM276749 US10188653, Example 19.21::US11034678, WO2015140658 Example 19.21::US9789110, 19.21::WO2015140658, Example 19.21

SMILES CCOc1ccccc1O[C@@H]1CCCN(C1)c1ncc(cn1)C(=O)NC(C)(C)CO

InChI Key InChIKey=WOITWYYPJBHODL-QGZVFWFLSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 276749   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM276749(US10188653, Example 19.21 | US11034678, WO20151406...)
Affinity DataIC50:  7.90nMpH: 7.4 T: 2°CAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM276749(US10188653, Example 19.21 | US11034678, WO20151406...)
Affinity DataIC50:  7.90nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM276749(US10188653, Example 19.21 | US11034678, WO20151406...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human DGAT2 expressed in Sf9 insect cell membrane using [1-14C]decanoyl-CoA and 1,2-didecanoyl-sn-glycerol as substrates assessed as in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM276749(US10188653, Example 19.21 | US11034678, WO20151406...)
Affinity DataIC50:  7.90nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 1 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM276749(US10188653, Example 19.21 | US11034678, WO20151406...)
Affinity DataIC50:  7.90nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white Polyplates (Perkin Elmer) in a total volume of 20 μL. To 14 o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent