BDBM276965 US10072001, Example 141::US10259811, Example 141

SMILES COc1cc(ccc1N1CCN(CC1)C1COC1)-c1cc2c(ncnc2[nH]1)-c1ccc(OC2CCN(CC2(F)F)C(=O)CO)c(c1)C#N

InChI Key InChIKey=LNIVPTBCCJSTCB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 276965   

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50:  0.687nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50:  0.763nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50:  0.687nMAssay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM276965(US10072001, Example 141 | US10259811, Example 141)
Affinity DataIC50:  0.763nMpH: 7.0Assay Description:Enzymatic activity of IKKε and TBK1 was measured using a homogeneous time resolved fluorescence resonance energy transfer (TR-FRET) assay that m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent