BDBM279116 1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)methyl]-5-thiazol-2-yl-pyrazolo[4,3-b]pyridin-7-amine::US10034861, Example 147::US10512632, Example 147::US10618913, Example S147::US10766893, Example S147::US10806718, Example 147::US11026923, Example 147::US11491140, Example 147::US11634416, Example 147

SMILES CC(C)n1nc(C)c2nc(cc(NCc3cnn(C)c3)c12)-c1nccs1

InChI Key InChIKey=TVGMRVMYCDHOEG-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 279116   

LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 uL samples containing a fixed amount of the PDE1 enzyme (suff...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  28nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM279116(1-isopropyl-3-methyl-N-[(1-methylpyrazol-4-yl)meth...)
Affinity DataIC50:  2.10nMpH: 7.6 T: 2°CAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent