BDBM280364 2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyrrolo[2,3-d]pyrimidin-4-yl}pyridin-4-amine::US10030004, Compound 30::US10501436, Compound 30::US11053216, Compound 30::US11702401, Compound 30

SMILES COc1ccc(Cn2ccc3c(Nc4cc(ncc4C(C)C)-c4ncccc4F)ncnc23)cc1

InChI Key InChIKey=NVZWXPUBNZUNFM-UHFFFAOYSA-N

Data  24 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280364   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  5.90E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  1.35E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  23.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  26.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  1.35E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  5.90E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  7.30E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  23.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  26.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  1.35E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  5.90E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  7.30E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  23.7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  26.4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  1.35E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  5.90E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  7.30E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  23.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  26.4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent
LigandPNGBDBM280364(2-(3-fluoropyridin-2-yl)-5-(propan-2-yl)-N-{7H-pyr...)
Affinity DataIC50:  7.30E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent