BDBM280370 2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-pyrazolo[3,4-d]pyrimidin-4-yl}pyridin-4-amine::US10030004, Compound 36::US10501436, Compound 36::US11053216, Compound 36::US11702401, Compound 36

SMILES COc1ccc(Cn2ncc3c(Nc4cc(ncc4C(C)C)-c4cc(Cl)ccc4F)ncnc23)cc1

InChI Key InChIKey=CKODUGCWZCWIRZ-UHFFFAOYSA-N

Data  24 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 280370   

TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  17.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Mus musculus (Mouse))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  8.93E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  17.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetBone morphogenetic protein receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

In DepthDetails US Patent
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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  8.93E+3nMMore data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70nMMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  17.7nMMore data for this Ligand-Target Pair

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TargetBone morphogenetic protein 10(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMMore data for this Ligand-Target Pair

Target InfoPDB
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Ligand InfoPC cidPC sid

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TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  8.93E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
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TargetBone morphogenetic protein receptor type-1A(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+4nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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TargetActivin receptor type-1B(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  3.70nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
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Ligand InfoPC cidPC sid

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TargetTGF-beta receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  17.7nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ3 family of Ser/Thr kinases. The kinases ...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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TargetActivin receptor type-1(Homo sapiens (Human))
Medivation Technologies

US Patent

LigandBDBM280370(2-(5-chloro-2-fluorophenyl)-5-(propan-2-yl)-N-{1H-...)Copy SMILESCopy InChI

Affinity DataIC50:  8.93E+3nMAssay Description:Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t...More data for this Ligand-Target Pair

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Ligand InfoPC cidPC sid

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