BDBM281415 6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phenyl]-4-({2-[(2-hydroxyethyl)-(methyl-sulfonyl)amino]ben-zyl}amino)-N-methyl-1H-pyrazolo[4,3-c]pyridine-3-carboxamide::US10022376, Example 24

SMILES CNC(=O)c1n[nH]c2cc(nc(NCc3ccccc3N(CCO)S(C)(=O)=O)c12)-c1cc(F)c(O)cc1CC(F)(F)F

InChI Key InChIKey=OHJSXUGZVUQCOA-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 281415   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  16.5nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  69.6nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  29.9nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  2.90nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  16.5nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  69.6nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM281415(6-[5-fluoro-4-hydroxy-2-(2,2,2-trifluoroeth-yl)phe...)
Affinity DataIC50:  29.9nMpH: 7.4 T: 2°CAssay Description:Test article was solubilized in dimethyl sulfoxide (DMSO) to a stock concentration of 30 mM. An 11-point half log dilution series was created in DMSO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent