BDBM28236 CHEMBL199145::N-[(4-fluorophenyl)methyl]-8-hydroxy-1,6-naphthyridine-7-carboxamide::naphthyridine carboxamide, 21

SMILES Oc1c(ncc2cccnc12)C(=O)NCc1ccc(F)cc1

InChI Key InChIKey=AGPDHYVMIWYSBH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 28236   

TargetGag-Pol polyprotein [1148-1435](Human immunodeficiency virus type 1)
Gsk

LigandPNGBDBM28236(CHEMBL199145 | N-[(4-fluorophenyl)methyl]-8-hydrox...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:Purified recombinant integrase was first combined in a complex with biotinylated donor DNA- streptavidin-coated SPA beads. The complex was preincubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28236(CHEMBL199145 | N-[(4-fluorophenyl)methyl]-8-hydrox...)
Affinity DataIC50:  33nMAssay Description:Inhibition of strand transfer for HIV-1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28236(CHEMBL199145 | N-[(4-fluorophenyl)methyl]-8-hydrox...)
Affinity DataIC50:  33nMAssay Description:Inhibition of HIV1 recombinant integrase catalyzed strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28236(CHEMBL199145 | N-[(4-fluorophenyl)methyl]-8-hydrox...)
Affinity DataIC50:  33nMAssay Description:Inhibition of recombinant HIV1 integrase strand transfer activity using immobilized DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM28236(CHEMBL199145 | N-[(4-fluorophenyl)methyl]-8-hydrox...)
Affinity DataIC50:  33nMAssay Description:Inhibition of strand transfer process of HIV1 integraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed