BDBM282797 (S)-6-(4-(4-fluroophenyl)-1-(1-hydroxybutan-2-yl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile::US9884868, Example 6'

SMILES CC[C@@H](CO)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=QYXUDJJTDANZPN-HNNXBMFYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 282797   

TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282797((S)-6-(4-(4-fluroophenyl)-1-(1-hydroxybutan-2-yl)-...)
Affinity DataIC50:  1.02E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282797((S)-6-(4-(4-fluroophenyl)-1-(1-hydroxybutan-2-yl)-...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent