BDBM282803 6-(4-(4-fluorophenyl)-1-(3-hydroxy-3-methylbutyl)- 1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3- carbonitrile::US10287295, Example 12'::US11352360, Example 12'::US9884868, Example 12'

SMILES CC(C)(O)CCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=RUFJJHLOWAYYNK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 282803   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282803(6-(4-(4-fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-...)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282803(6-(4-(4-fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-...)
Affinity DataIC50:  2.10nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282803(6-(4-(4-fluorophenyl)-1-(3-hydroxy-3-methylbutyl)-...)
Affinity DataIC50:  2.10nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent